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目的探讨24h尿微量白蛋白(24h UmAlb)、血清胱抑素C(SCys C)及二者联合检测在肿瘤患者药物性肾损伤早期诊断中的临床价值。方法研究对象分为出现肾损伤组、未出现肾损伤组和健康对照组,检测24h UmAlb、SCys C、肌酐和尿素氮。结果肾损伤组24h UmAlb、SCys C水平高于未出现肾损伤组和健康对照组;未出现肾损伤组24h UmAlb和SCys C水平高于健康对照组。结论 24h UmAlb和SCys C水平是提示肿瘤患者出现药物性肾损害的灵敏指标,二者联合检测有利于肿瘤患者药物性肾功能损害的早期发现和治疗。
Objective To investigate the clinical value of 24-h urine microalbuminuria (24h UmAlb), serum cystatin C (SCys C) and their combined detection in the early diagnosis of drug-induced renal injury in cancer patients. Methods The subjects were divided into renal injury group, no renal injury group and healthy control group. 24h UmAlb, SCys C, creatinine and urea nitrogen were detected. Results The levels of UmAlb and SCys C in renal injury group were higher than those without renal injury group and healthy control group. The levels of UmAlb and SCys C in renal injury group were higher than those in healthy control group. Conclusions 24h UmAlb and SCys C levels are sensitive indicators of drug-induced renal damage in tumor patients. The combined detection of these two drugs is beneficial to the early detection and treatment of drug-induced renal dysfunction in cancer patients.