复方穿心莲浸膏小鼠灌胃LD_(50)=2.18g/kg,穿心莲浸膏小鼠灌胃LD_(50)=13.19g/kg(均以穿心莲内酯含量计)。它们对小鼠由氨雾刺激引起的咳嗽均有止咳作用,但前者的效应优于后者(P<0.05)。复方制剂还对家兔由疫苗和大肠杆菌所致的发热有解热作用,而后者未显示此效应。两者对蛋清或琼脂所致大鼠关节肿、化学性引起的小鼠耳廓毛细血管扩张均无消肿抗炎作用 The compound Andrographis paniculata extract mice were given LD_(50)=2.18g/kg by gavage. Andrographis paniculata extract mice were given LD_(50)=13.19g/kg by gavage (both with andrographolide content). They all had antitussive effect on cough caused by ammonia mist stimulation, but the former had better effect than the latter (P<0.05). The compound preparation also exerted antipyretic effects on rabbits due to fever caused by vaccines and E. coli, while the latter did not show this effect. Both had no swelling and anti-inflammatory effects on mouse rat auricles caused by egg white or agar, and chemically induced auricle telangiectasia in mice.