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目的评价福莫特罗治疗支气管哮喘的临床疗效和安全性。方法计算机检索中英文数据库,纳入加或不加布地奈德,福莫特罗对比安慰剂治疗支气管哮喘的随机对照试验(RCT)和系统评价(SR)文献,对纳入的随机对照试验进行方法学质量评价和Meta分析,并参考现有的质量评价和Meta分析结论。结果纳入符合入选标准的7项随机对照试验和6项系统评价文献。Meta分析结果显示:1福莫特罗对比安慰剂:福莫特罗可显著增加哮喘急性发作需要住院的概率,其余二者均无显著差异;2布地奈德福莫特罗对比布地奈德:布地奈德福莫特罗可显著改善哮喘患者的呼气流量峰值(PEF)和第一秒用力呼气量(FEV1),同时显著增加哮喘儿童急性发作需要住院的概率,当布地奈德使用常规剂量时还会显著增加哮喘患者急性发作需要口服糖皮质激素的概率,但二者的不良反应无显著差异。结论本研究结果显示,单独使用福莫特罗治疗哮喘有弊无利,因此不推荐单独应用;福莫特罗联合布地奈德,尤其是联合低剂量的布地奈德,不仅能减少哮喘发作,提高患者的生活质量,而且还能改善肺功能,是一种相对安全的治疗方法。
Objective To evaluate the clinical efficacy and safety of formoterol in the treatment of bronchial asthma. METHODS: The randomized controlled trials (RCTs) and systematic reviews (SRs) of computerized Chinese and English databases were enrolled in randomized controlled trials (RCTs) and placebo-controlled placebo for bronchial asthma with or without budesonide, and formoterol. Methods were included in randomized controlled trials Quality evaluation and meta-analysis, and make reference to the existing quality evaluation and conclusion of meta-analysis. Results Seven randomized controlled trials and six reviews of systematic reviews that met the inclusion criteria were included. Meta analysis showed that: 1 Formoterol compared with placebo: formoterol can significantly increase the probability of hospitalization for acute exacerbation of asthma, the other two had no significant difference; 2 budesonide formoterol vs budesonide: The budesonide formoterol significantly improves the peak expiratory flow (PEF) and forced expiratory volume in the first second (FEV1) of patients with asthma, and at the same time significantly increases the probability of hospitalization for acute attacks in asthmatic children. When budesonide uses conventional The dose also significantly increased the probability of requiring oral corticosteroids for acute episodes of asthma, but there was no significant difference between the two. Conclusion The results of this study show that the use of formoterol in the treatment of asthma has both disadvantages and disadvantages and is therefore not recommended for use alone. Combining formoterol with budesonide, especially with low-dose budesonide, not only reduces asthma attacks, Improve patient quality of life, but also improve lung function, is a relatively safe treatment.