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目的研究在2010—2012年期间无锡市第四人民医院核医学诊疗中心合成18F-FDG时化学合成室中的辐射剂量率与参与反应的氟离子的活度的关系,分析放射性药物自动分装仪和自制防护盒的使用对降低分装人员的受照射剂量的作用。方法通过加速器产生不同活度的氟离子参加化学反应,利用γ射线辐射水平剂量仪监测化学合成室中不同工作点的辐射剂量率,分析辐射剂量率和氟离子活度的线性关系。监测在分装药物时使用和不使用防护盒时手臂的受照射剂量率的差异,并计算分装人员的手臂的年辐射当量剂量。结果化学合成室中的辐射剂量率和反应的氟离子的活度有直接的正比关系,同时使用一种自制的防护盒能使分装人员在分装药物时手臂的辐射当量剂量降低约90%。结论依据患者人数选择适当活度的氟离子参与反应和使用自制的药物分装防护盒能大大减少药物合成人员的外照射剂量。据此,该中心合成人员在2010—2012年期间的年个人当量剂量为0.71 mSv和手臂的年当量剂量(估算68 mSv)均不超过国家的职业人员个人5年内平均每年20 mSv和手臂500 mSv年当量剂量限值。
Objective To study the relationship between the radiation dose rate and the activity of fluoride ion participating in the reaction in the synthesis room of 18F-FDG during the period from 2010 to 2012 in the Nuclear Medicine Clinic of Fourth People’s Hospital of Wuxi City. And the use of self-made protective boxes to reduce the dose of dispensing personnel role. Methods Fluoride ions with different activities were generated by accelerator to participate in the chemical reaction. The radiation dose rate at different operating points in the chemical synthesis chamber was monitored by using γ-ray radiation level dosimeter. The linear relationship between radiation dose rate and fluoride activity was analyzed. Monitor the difference in the irradiated dose rate of the arm when dispensing the protective case with and without the protective case, and calculate the annual radiation equivalent dose of the arm of the dispensing person. Results There was a direct proportional relationship between the radiation dose rate in the chemical synthesis chamber and the activity of the fluoride ion in the reaction and the use of a self-made protective case enabled the dispensers to reduce their arm radiation dose by about 90% . Conclusion According to the number of patients choose the appropriate activity of fluoride ion involved in the reaction and the use of self-made drug dispensing protective box can greatly reduce the external dose of drug synthesis staff. Accordingly, the annual synthetic equivalent dose of 0.71 mSv and the arm of the center’s synthetic workers during 2010-2012 (estimated at 68 mSv) does not exceed the national average of 20 mSv per individual for 5 years and 500 mSv per arm Annual equivalent dose limit.