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目的探讨核因子NF-κB(nuclear factoro fkappa B,NF-κB)及细胞间粘附分子-1(intercellul aradhesionmo lecule-1,ICAM-1)在非小细胞肺癌(non-small cell lung cancer,NSCLC)中的表达及其临床意义。方法采用免疫组织化学SABC技术,检测NF-κBp65及ICAM-1在40例非小细胞肺癌石蜡包埋组织标本中的表达,并比较二者与临床多种因素(包括性别、年龄、组织学类型、分化程度、瘤体大小、TNM分期、吸烟指数及远处转移)的关系,以40例肺部非恶性组织标本为对照。结果肺癌组织中NF-κBp65及ICAM-1的表达明显高于其在非恶性肺组织中的表达(P<0.01)。肺癌组织中NF-κBp65和ICAM-1在腺癌中的表达明显高于鳞癌(P<0.01);ICAM-1在低分化肺癌组织中的表达比在高-中分化组织中显著增强(P<0.05);NF-κBp65和ICAM-1的表达在有远处转移时比无远处转移时显著性增强(P<0.01);而在不同年龄、性别、瘤体大小、临床分期及吸烟指数的肺癌组织中NF-κBp65和ICAM-1的表达没有显著性差异(P>0.05);非小细胞肺癌组织中NF-κBp65的表达与ICAM-1的表达呈正相关(P<0.01)。结论NF-κBp65及ICAM-1在非小细胞肺癌中有高表达;且其表达与肺癌的浸润转移密切相关;同时在非小细胞肺癌组织中NF-κBp65的表达与ICAM-1的表达呈正相关。
Objective To investigate the effects of nuclear factor-fkappa B (NF-κB) and intercellular adhesion molecule-1 (ICAM-1) on non-small cell lung cancer (NSCLC) ) And its clinical significance. Methods The immunohistochemical SABC technique was used to detect the expression of NF-κBp65 and ICAM-1 in 40 non-small cell lung cancer paraffin-embedded tissues. The clinical data of two groups were compared with those of clinical factors including gender, age, histological type , The degree of differentiation, tumor size, TNM stage, smoking index and distant metastasis), 40 cases of lung non-malignant tissue specimens as a control. Results The expressions of NF-κBp65 and ICAM-1 in lung cancer tissues were significantly higher than those in non-malignant lung tissues (P <0.01). The expression of NF-κBp65 and ICAM-1 in lung cancer tissues was significantly higher than that in squamous cell carcinoma (P <0.01). The expression of ICAM-1 in poorly differentiated lung cancer tissues was significantly higher than that in high-moderately differentiated tissues <0.05). The expressions of NF-κBp65 and ICAM-1 were significantly increased when there was distant metastasis than those without distant metastasis (P <0.01). However, the expressions of NF-κBp65 and ICAM-1 were significantly different in different age, gender, tumor size, clinical stage and smoking index (P> 0.05). There was a positive correlation between the expression of NF-κBp65 and the expression of ICAM-1 in non-small cell lung cancer (P <0.01). Conclusions NF-κBp65 and ICAM-1 are highly expressed in non-small cell lung cancer (NSCLC). The expression of NF-κBp65 and ICAM-1 is closely related to the infiltration and metastasis of lung cancer. Meanwhile, the expression of NF-κBp65 is positively correlated with the expression of ICAM-1 in non-small cell lung cancer .