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为了研究某种保健食品的安全性,进行了急性毒性和30d喂养试验。按照《保健食品检验与评价技术规范》中小鼠经口急性毒性试验和30d喂养试验方法进行,得出结果,小鼠经口MTD大于12g/kg(bw),各剂量组大鼠的一般情况、体质量、食物利用率、脏器质量、脏器系数均无异常改变。血常规和生化指标结果显示,各项指标均在正常范围内。大鼠的各脏器病理组织检查与阴性对照组比较,差异无显著性(p>0.05)。该保健食品属于无毒类,未发现该产品对被检动物的大体解剖与主要脏器产生有意义的病理变化。
In order to study the safety of certain health foods, acute toxicity and 30d feeding trials were conducted. According to “oral health test and evaluation of technical specifications” in mice oral acute toxicity test and 30d feeding test, the results showed that mice with oral MTD greater than 12g / kg (bw), the general situation of each dose group rats, Body weight, food utilization, organ quality, organ coefficient no abnormal changes. Blood and biochemical indicators results show that the indicators are within the normal range. There was no significant difference in the histopathological examination of each organ in rats compared with the negative control group (p> 0.05). The health food is non-toxic, did not find the product of the general anatomy of the animals were detected and the main organs have a meaningful pathological changes.