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蛇毒中有许多种酶,其中有一组酶可使纤维蛋白元和纤维蛋白产生不同程度的降解。由Bothrops atrox moojenii提取的Batroxobin(也叫做Defibrase)以及AgkistrodonRhodostoma中的Ancrod,都只裂解纤维蛋白元分子的肽A,所形成的纤维蛋白对纤溶酶的作用较凝血酶形成的更敏感。上述作用称为凝血酶样作用,这类酶亦称为凝血酶样酶。另外,由于以上两种酶均不激活因子ⅩⅢ,但也有人认为可以活化因子ⅩⅢ,不过是较凝血酶弱,不激活因子ⅩⅢ而形成的纤维蛋白是可溶性的,易被网状内皮系统所清除。尖吻蝮蛇(Agkistrodon acutus)蛇毒去纤酶不仅降解纤维蛋白元分子的肽,不激活因子ⅩⅢ,而且还能直接作用于纤维蛋白原或纤维蛋白,即凝血酶样酶效应和纤溶酶样效应。
There are many kinds of enzymes in snake venom, of which one group of enzymes can make fibrin and fibrin produce different degrees of degradation. Batroxobin (also known as Defibrase) extracted from Bothrops atrox moojenii and Ancrod from Agkistrodon Rhodostoma cleave only the fibrin molecule A of the peptide, forming a fibrin that is more sensitive to plasmin than thrombin formation. The above effect is called thrombin-like effect, also known as thrombin-like enzyme. In addition, since neither of the above two enzymes activates factor XIII, it is also believed that factor XIII can be activated, but fibrin, which is weaker than that of thrombin, does not activate factor XIII, is easily cleared by the reticuloendothelial system . Agkistrodon acutus snake venom defibrase not only degrades the fibrin molecule peptide but does not activate factor XIII but also acts directly on fibrinogen or fibrin ie the thrombin-like enzyme effect and the plasmin-like effect.