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1Skp2的基因定位和结构特点Skp2是由Zhang等[1]1995年从人的成纤维细胞中首次克隆,荧光原位杂交证实Skp2基因定位于人类染色体的5pl3区,全长31962bp。Skp2基因编码的蛋白产物Skp2蛋白由436个氨基酸残基构成,其分子质量为45kD,因此有人也称之
Skp2 was first cloned from human fibroblasts by Zhang et al. [1] in 1995. Fluorescence in situ hybridization confirmed that the Skp2 gene is located in the 5pl3 region of human chromosome with a full-length of 31962 bp. The Skp2 protein encoded by the Skp2 gene consists of 436 amino acid residues and has a molecular mass of 45 kD, so it is also called