目的　探讨肝素治疗因抗磷脂抗体所致反复性妊娠丢失及对孕妇血液中抗体的影响。　方法　前瞻性地将 4 8例反复性妊娠丢失患者 (排除遗传、感染、内分泌及子宫附件等导致流产的其它因素 ) ,狼疮抗凝抗体 (lupusanticoagulation ,LA)和 /或抗心磷脂抗体 (anticardiolipinantibody ,ACA)阳性患者 ,就诊后一经诊断为妊娠即随机分为两组 ,各 2 4例 ,分别给予肝素 (研究组 )和小剂量阿司匹林加强的松 (对照组 )治疗 ,观察两组治疗前后LA和ACA的量和妊娠结局。　结果　 ( 1)研究组 2 4例中 ,2 1例足月产 ( 87.5 0 % )、2例早产 ( 8 33% )、新生儿Apgar评分 5min≥ 8分 ;1例流产( 4 .17% ) ,活婴 2 3例 ,活产率 95 .83% ( 2 3/2 4 ) ,与对照组的 19例足月产 ( 79.17% )相比 ,差异无显著性 (P >0 .0 5 )。 ( 2 )研究组 2 4例妊娠者中 17例抗体被清除 ,清除率为 70 .83% ,与对照组 2 9.17% ( 7/2 4 )比较 ,差异有显著性 (P <0 .0 1)。　结论　肝素对抗磷脂抗体所致的反复妊娠丢失治疗效果肯定 ,对清除抗体效果肯定 Objective To investigate the effect of heparin on the loss of recurrent pregnancy induced by antiphospholipid antibody and the antibody in blood of pregnant women. Methods Forty-eight patients with recurrent pregnancy loss (excluding other factors leading to miscarriage such as genetic, infection, endocrine and uterine attachment), lupus anticoagulation (LA) and / or anticardiolipin antibody ACA positive patients were diagnosed as pregnancy after treatment were randomly divided into two groups of 24 cases, respectively, given heparin (study group) and low-dose aspirin enhanced pine (control group) treatment, the two groups before and after treatment LA and The amount of ACA and pregnancy outcome. RESULTS: Among 24 cases in study group, 21 cases were full-term (87.5%), 2 were premature (8 33%), neonatal Apgar score was 5 min≥8 and 1 case (4.17% (P <0.05). There were no significant differences between the control group and the control group (19 cases, 79.17%) in the control group (P> 0.05) . (2) In the study group, 17 of 24 pregnant women were eliminated with a clearance rate of 70.83%, which was significantly different from that of control group (9.17%, 7/2 4) (P <0.01 ). Conclusion Heparin on anti-phospholipid antibodies caused by repeated pregnancy loss treatment effect is certainly positive effect of antibody clearance