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目的:观察复发性流产患者血清Th1/Th2细胞因子失衡及补肾固冲汤加减干预作用。方法:随机将复发性流产患者120例分为西药组和中药组,选取正常妊娠患者60例,做空白对照组。空白对照组不给予任何措施;西药组给予黄体酮注射液肌肉注射,15 mg/次,3次/周;中药组给予黄体酮注射的同时补肾固冲汤加减口服,100m L/次,日2次。分别于0、2、4、6、8、10、12周检测血清HCG、孕酮水平,观察各组患者流产情况。并于治疗前后检测各组患者血清TNF-α、IL-4细胞因子含量,观察Th1/Th2细胞因子免疫平衡情况。结果:治疗前,复发性流产患者血清HCG、孕酮水平明显低于空白对照组,经治疗后,水平均有不同程度上升,以中药组效果较为明显;计算各组有效率(分娩率)、中药组有效率(分娩率)明显升高;治疗前,与空白对照组比较,西药组和中药组Th1/Th2平衡明显向Th1型偏移;治疗后,西药组和中药组Th1/Th2平衡明显向Th2型偏移。结论:复发性流产患者血清Th1/Th2细胞因子明显向Th1型方向失衡,补肾固冲汤加减能有效提高临床治愈率,并使Th1/Th2细胞因子明显向Th2型偏移。
Objective: To observe the imbalance of serum Th1 / Th2 cytokines in patients with recurrent spontaneous abortion and the intervention of Bushen Guchong Decoction. Methods: 120 cases of recurrent spontaneous abortion were randomly divided into western medicine group and traditional Chinese medicine group. 60 normal pregnant women were selected as blank control group. The blank control group did not give any measures; Western medicine group given progesterone injection intramuscularly, 15 mg / time, 3 times / week; Chinese medicine group given progesterone injection while Bushen Guchong Decoction orally, 100m L / time, day 2 Times. Serum HCG and progesterone levels were measured at 0, 2, 4, 6, 8, 10, and 12 weeks respectively to observe abortion status in each group. Serum levels of TNF-α and IL-4 were measured before and after treatment, and the immune balance of Th1 / Th2 cytokines was observed. Results: Before treatment, the levels of serum HCG and progesterone in patients with recurrent spontaneous abortion were significantly lower than those in the blank control group. After treatment, the levels of serum HCG and progesterone were increased to some extent. The effective rate (delivery rate) Compared with the blank control group, the balance of Th1 / Th2 in western medicine group and traditional Chinese medicine group obviously shifted to Th1 type before treatment; after treatment, the balance of Th1 / Th2 in western medicine group and traditional Chinese medicine group was obvious Offset to Th2 type. Conclusion: Th1 / Th2 cytokines in patients with recurrent spontaneous abortion obviously unbalanced toward Th1 type. Bushen Guchong Decoction can effectively improve the clinical cure rate and shift Th1 / Th2 cytokines to Th2 type.