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目的:分析不同证型抑郁症患者中西医结合治疗后抑郁情绪及认知功能改善情况。方法:选择2014年—2015年医院接诊的120例抑郁症患者进行研究,按照随机数表法将120例患者平均分为观察组和对照组两组,每组60例患者。对照组患者单纯给予西医常规抗抑郁剂-帕罗西汀片,观察组患者在对照组西医治疗的基础上,根据患者的中医证型进行中医治疗。两组患者治疗疗程均为8周,在患者治疗前、治疗后2周、治疗后4周、治疗后8周,分析两组患者临床治疗疗效,比较两组患者治疗前后HAMD、HAMA评分,观察并记录两组患者不良反应情况。结果:对照组患者临床治疗总有效率为73.33%,观察组患者临床治疗总有效率为90.00%,观察组明显高于对照组,两组患者临床治疗疗效差异具有统计学意义(P<0.05)。两组患者治疗前、治疗后2周HAMD评分差异不具统计学意义(P>0.05);两组患者治疗后4周、治疗后8周HAMD评分差异显著(P<0.05)。两组患者治疗前、治疗后2周HAMA差异不具统计学意义(P>0.05)。两组患者治疗后4周、治疗后8周HAMA差异明显(P<0.05)。两组患者治疗过程中出现不同程度的口干、恶心、排尿困难、食欲减退、便秘等不良反应。对照组患者总不良反应发生率为13.33%(8/60);观察组患者总不良反应率为6.67%(4/60)。两组患者不良反应情况差异不明显(P>0.05)。结论:根据抑郁症患者不同的中医证型进行中西医结合治疗后,患者的抑郁情绪及认知功能改善良好,临床治疗疗效显著提高,不良反应发生率下降,中西医结合的理念值得在临床推广应用。
OBJECTIVE: To analyze the improvement of depression and cognitive function after the treatment of TCM and WM in patients with different syndromes. Methods: A total of 120 patients with depression admitted to our hospital from 2014 to 2015 were selected and divided into observation group and control group according to the random number table method. Each group included 60 patients. Patients in the control group were given conventional western medicine anti-depressant-paroxetine tablets only. The patients in the observation group were treated with traditional Chinese medicine according to TCM syndromes in the control group. The two groups of patients were treated for 8 weeks, before treatment, 2 weeks after treatment, 4 weeks after treatment, 8 weeks after treatment, the clinical efficacy of the two groups were analyzed. HAMD and HAMA scores were compared between the two groups before and after treatment Adverse reactions were recorded in both groups. Results: The total effective rate of clinical treatment in the control group was 73.33%. The total effective rate of clinical treatment in the observation group was 90.00%. The observation group was significantly higher than that of the control group. The difference between the two groups was statistically significant (P <0.05) . There was no significant difference in HAMD scores between the two groups before treatment and two weeks after treatment (P> 0.05). There was significant difference in HAMD scores between the two groups 4 weeks after treatment and 8 weeks after treatment (P <0.05). The difference of HAMA between the two groups before treatment and 2 weeks after treatment was not statistically significant (P> 0.05). There was significant difference in HAMA between the two groups after 4 weeks of treatment and 8 weeks after treatment (P <0.05). Two groups of patients with varying degrees of dry mouth during treatment, nausea, dysuria, loss of appetite, constipation and other adverse reactions. The incidence of adverse reactions in the control group was 13.33% (8/60). The total adverse reaction rate in the observation group was 6.67% (4/60). Adverse reactions between the two groups showed no significant difference (P> 0.05). Conclusion: According to different TCM syndromes of patients with depression, the patients’ depression and cognitive function improve well, the clinical curative effect is significantly improved and the incidence of adverse reactions is decreased. The concept of integrated traditional Chinese and western medicine is worthy of clinical promotion application.