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目的:探讨自身免疫抗体与不良孕史及自然流产次数的关系。方法:采用病例对照研究方法,对2010年1月至2011年1月在就诊并确诊为早期自然流产的患者102例,正常生育妇女96例作为对照组。两组妇女均用酶联免疫吸附试验方法检测五种免疫抗体。结果:①病例组ACA、AoAb、AsAb、EmAb、ZpAb的阳性率分别为,五种抗体的阳性率较对照组显著增高,差异有统计学意义(P<0.05)。②病例组ACA、AsAb、ZpAb的阳性率随着流产次数的增加而增加,而流产次数增加AoAb和EmAb的阳性率无显著的变化。结论:ACA、AoAb、AsAb、EmAb和ZpAb与不良孕史有一定的相关性,且ACA、AsAb和ZpAb与流产次数之间有着相互的影响作用。
Objective: To investigate the relationship between autoimmune antibodies and adverse pregnancy history and the number of spontaneous abortion. Methods: A case-control study was conducted. From January 2010 to January 2011, 102 patients were diagnosed as early spontaneous abortion and 96 normal women were used as control group. Five groups of women tested for five kinds of immune antibodies by enzyme-linked immunosorbent assay. Results: ① The positive rates of ACA, AoAb, AsAb, EmAb and ZpAb in case group were significantly higher than those in control group (P <0.05). ② The positive rate of ACA, AsAb and ZpAb increased with the increase of miscarriage times, while there was no significant change of the positive rate of AoAb and EmAb. CONCLUSION: ACA, AoAb, AsAb, EmAb and ZpAb have some correlation with adverse pregnancy history, and ACA, AsAb and ZpAb have mutual influence on the number of abortion.