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研究ｐ５３蛋白异常表达与喉癌、下咽癌生物学行为的相关性。方法：用免疫组化方法（ＬＳＡＢ）检测４１例喉癌、下咽癌的手术标本ｐ５３蛋白表达，并分析其与ＴＮＭ分期，病理分级和淋巴结转移的关系。结果：４１例肿瘤有１９例ｐ５３蛋白表达分阳性，阳性率为４６．３％。ｐ５３蛋白异常表达与ＴＮＭ分期、病理分级和淋巴结转移均显著相关（Ｐ＜０．０５）、结论：ｐ５３蛋白与喉癌、下咽癌生物学行为密切相关，且具有预后价值。
To study the relationship between abnormal expression of p53 protein and the biological behavior of laryngeal cancer and hypopharyngeal cancer. Methods: Immunohistochemical method (LSAB) was used to detect the expression of p53 protein in surgical specimens of 41 cases of laryngeal and hypopharyngeal carcinomas, and their relationship with TNM staging, pathological grade and lymph node metastasis was analyzed. Results: Of the 41 tumors, 19 were positive for p53 protein, with a positive rate of 46.3%. The abnormal expression of p53 protein was significantly associated with TNM staging, pathological grade and lymph node metastasis (P<0.05). Conclusion: The p53 protein is closely related to the biological behaviors of laryngeal and hypopharyngeal carcinomas, and has a prognostic value.