近年来,随着糖尿病和冠心病的发病率逐渐增高,糖尿病患者的心血管疾病风险明显增加。冠心病的主要病变是动脉粥样硬化(AS),AS进程的主要表现是血管内膜增生,其标志为动脉血管壁的炎症细胞浸润和血管平滑肌细胞(VSMCs)的异常增殖。由此推断,影响血管内皮细胞增殖过程和调节细胞周期的遗传因素可能会对As过程产生影响,如目前的研究热点细胞周期蛋白依赖性激酶抑制蛋白 In recent years, with the increasing incidence of diabetes and coronary heart disease, patients with diabetes significantly increased the risk of cardiovascular disease. A major coronary artery disease is atherosclerosis (AS), the major manifestation of AS progression being intimal hyperplasia, which is marked by inflammatory cell infiltration in the arterial wall and abnormal proliferation of vascular smooth muscle cells (VSMCs). It is concluded that genetic factors that affect the process of vascular endothelial cell proliferation and regulate the cell cycle may have an impact on the As process, such as the current research hot spots cyclin-dependent kinase inhibitory protein