论文部分内容阅读
目的探讨氨氯地平联合阿托伐他汀治疗老年单纯收缩期高血压(ISH)对患者血压及血脂水平的影响。方法 120例ISH患者分成治疗组和对照组各60例,治疗组每天给予氨氯地平5～10mg、阿托伐他汀20mg口服,对照组每天给予氨氯地平5～10mg口服,观察两组治疗前后患者收缩压、舒张压和血脂的变化情况。结果治疗8W后治疗组在降低收缩压方面明显优于对照组,而在降低舒张压方面两组差异无统计学意义;治疗组治疗后HDL-C增高,TC、LDL-C、TG均降低,与治疗前比较差异有统计学意义,对照组治疗前后血脂的变化无统计学意义。两组均无明显不良反应。结论氨氯地平联合阿托伐他汀治疗ISH在降低收缩压和调脂方面明显优于单用氨氯地平,且未增加药物不良反应。
Objective To investigate the effect of amlodipine combined with atorvastatin on blood pressure and blood lipid in elderly patients with isolated systolic hypertension (ISH). Methods A total of 120 patients with ISH were divided into treatment group (60 cases) and control group (60 cases). The treatment group was treated with amlodipine 5 ~ 10 mg daily and atorvastatin 20 mg orally daily while the control group was given amlodipine 5 ~ 10 mg daily. Before and after treatment Patients with systolic blood pressure, diastolic blood pressure and lipid changes. Results After treatment for 8W, the treatment group was significantly better than the control group in reducing systolic blood pressure, while there was no significant difference in reducing diastolic blood pressure between the two groups. After treatment, HDL-C, TC, LDL-C and TG decreased, Compared with the pre-treatment difference was statistically significant, the control group before and after treatment of blood lipids did not change statistically significant. No significant adverse reactions in both groups. Conclusion Amlodipine combined with atorvastatin is superior to amlodipine in reducing systolic blood pressure and lipid-lowering in the treatment of ISH without increasing adverse drug reactions.