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激活蛋白AP-2是一种序列特异性的转录因子,由AP-2α,AP-2β,AP-2γ,AP-2δ和AP-2ε等几个关系密切、结构保守的成员组成,参与细胞增殖分化、凋亡和癌变的调控。在多种不同类型肿瘤的发生、发展过程中,AP-2都存在异常表达,且与肿瘤预后有着密切的关系。同时,AP-2对肿瘤的调节具有抑癌或促癌的双向效应,这一作用因肿瘤的原发组织不同而不同。
Activator protein AP-2 is a sequence-specific transcription factor composed of several closely related, conserved structural members, such as AP-2α, AP-2β, AP-2γ, AP-2δ and AP- Differentiation, apoptosis and cancer regulation. AP-2 is abnormally expressed in the occurrence and development of many different types of tumors, and has a close relationship with tumor prognosis. At the same time, the regulation of AP-2 on the tumor has the two-way effect of suppressing cancer or promoting cancer, and this effect varies with the primary tissue of the tumor.