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目的比较缺氧诱导因子-1α(hypoxia inducible factor,HIF-1α)在前置胎盘患者和正常孕妇胎盘组织中的表达及其临床意义。方法选取西安市长安医院2012年5月至2014年5月诊治的130例前置胎盘患者的胎盘组织为观察组,以同期诊治的110例正常孕妇的胎盘组织为对照组,分别利用免疫组织化学技术(SP法)检测两组胎盘组织中HIF-1α的表达情况,观察计数并计算阳性细胞的百分率,分别测定积分光密度(integral optical density,IOD)值,比较并分析相关结果。结果对照组HIF-1α阳性表达率(40.9%)低于观察组(64.6%)(P<0.05),对照组的IOD均值(29.9823±14.2743)低于观察组(41.3417±27.5373)(P<0.05)。结论 HIF-1α可能参与前置胎盘发生的过程。
Objective To compare the expression of hypoxia inducible factor-1α (HIF-1α) in placenta of placenta previa and normal pregnant women and its clinical significance. Methods Placenta of 130 patients with placenta previa diagnosed and treated in Chang’an Hospital of Xi’an from May 2012 to May 2014 were selected as the observation group. The placental tissues of 110 normal pregnant women treated by the same period were selected as the control group, and immunohistochemistry The expression of HIF-1α in two groups of placenta was detected by SP method. The counts were counted and the percentage of positive cells was calculated. The integral optical density (IOD) values were measured respectively. The results were compared and analyzed. Results The positive rate of HIF-1α in control group (40.9%) was lower than that in observation group (64.6%) (P <0.05). The mean IOD of control group (29.9823 ± 14.2743) was lower than that of observation group (41.5417 ± 27.5373) ). Conclusion HIF-1α may be involved in the process of placenta previa.