上皮型钙粘蛋白是一种钙依赖性细胞黏附分子,为一类分布于上皮细胞表面的跨膜糖蛋白,可以介导细胞与细胞、细胞与细胞外基质间的相互作用。研究表明,肿瘤细胞中上皮型钙粘蛋白的丢失不仅导致细胞间接触的减弱,还导致组织恶性变及肿瘤细胞的浸润、转移,上皮型钙粘蛋白可能在肿瘤向恶性表型发展的过程中起重要的作用。就其结构、功能、分布、调节因素及在宫颈癌中的表达以及相关的治疗措施作一综述。 E-cadherin is a calcium-dependent cell adhesion molecule, a type of transmembrane glycoprotein distributed on the surface of epithelial cells that mediates the interaction of cells with cells, cells and extracellular matrix. Studies have shown that the loss of epithelial cadherin in tumor cells not only leads to the decrease of cell-to-cell contact, but also leads to the malignant transformation of tissues and the infiltration and metastasis of tumor cells. E-cadherin may be involved in the development of malignant phenotypes Play an important role. On the structure, function, distribution, regulatory factors and expression in cervical cancer and related treatment measures are reviewed.