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目的探讨EBV病毒感染的民族差异性。方法收集广西罗城仫佬族自治县健康成人血清共3 060例(仫佬族1 497例,毛南族963例,汉族600例)及其基本信息,酶联免疫吸附试验(ELISA)检测血清中VCA-IgA、Zta-IgA、EBNA1-IgA 3种抗体的水平,结果以校正相对吸光度值(ArA)表示,分别统计3种抗体的阳性率,分析民族之间的差异。结果 VCA-IgA、Zta-IgA阳性率仫佬族和毛南族(9.22%、8.28%和8.83%、7.48%)高于汉族(5.67%、3.670%),差异有统计学意义(P<0.05)。结论广西罗城仫佬族自治县成人EB病毒感染率较高,在同一年龄段内仫佬族、毛南族人群罹患鼻咽癌的风险比汉族高。
Objective To investigate the ethnic differences of EBV infection. Methods A total of 3 060 cases of serum (1 497 Mulam, 963 Maonan, 600 Han nationality) and their basic information were collected from the healthy adults in Geluo Autonomous County of Guangxi Zhuang Autonomous Region. Enzyme linked immunosorbent assay (ELISA) -IgA, Zta-IgA and EBNA1-IgA. The results were expressed as corrected relative absorbance (ArA). The positive rates of three antibodies were calculated and the differences among different ethnic groups were analyzed. Results The positive rates of VCA-IgA and Zta-IgA were higher in Mulao and Maonan (9.22%, 8.28% and 8.83%, 7.48%) than those in Han (5.67% and 3.670%, respectively) . Conclusion The prevalence of Epstein-Barr virus (EBV) in adults in Luocheng Mulao Autonomous County of Guangxi Province is relatively high. Mulao and Maonan people have a higher risk of developing nasopharyngeal cancer than Han nationality in the same age group.