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使用固相提取柱作为液-液提取分离尿中药物的一种改进已得到普及,因为其回收率高而且操作简便、快速、准确性好.省去了费时的离心、过滤步骤,并杜绝了由于乳化而引起的样品损失.另外,使用一次性提取柱可减少手接触生物样品的污染、固相提取方法(SPE)已报道用于单一药物或结构相关的一类药物,至今未有报道将一种固相提取方法用于多种碱性治疗药物的监测或滥用药物的检验.
Improvements in the use of solid-phase extraction columns for liquid-liquid extraction of urine medications have gained popularity due to their high recovery rates and their ease of use, rapidity and accuracy, eliminating the time-consuming steps of centrifugation, filtration and elimination In addition, the use of disposable extraction columns to reduce hand-to-hand contamination of biological samples, the solid-phase extraction method (SPE) has been reported for a single drug or a structurally related class of drugs that has not been reported so far A solid-phase extraction method for the monitoring of a number of basic therapies or the testing of drug abuse.