论文部分内容阅读
目的探讨感染乙型肝炎病毒(HBV)的父亲血清中乙型肝炎病毒脱氧核糖核酸(HBV-DNA)载量对其新生儿是否携带HBV-DNA的影响,以明确需要阻断HBV父婴垂直的人群。方法以父亲乙肝病毒表面抗原(HBs Ag)阳性,母亲乙肝病毒表面抗原(HBs Ag)以及HBV-DNA均阴性的56对夫妻作为研究对象,收集夫妻双方血清以及新生儿的脐带血血清,检测血清中乙型肝炎标志物、HBV-DNA载量。以新生儿HBV-DNA载量结果作为分组依据,比较两组父亲HBV-DNA载量。结果以新生儿HBV-DNA载量结果作为分组依据,新生儿血清HBV-DNA阳性父亲HBV-DNA的载量显著高于新生儿HBV-DNA阴性者父亲HBV-DNA的载量(P<0.01)。结论男性血清HBV-DNA阳性并且载量>106copies/m L是HBV的父婴垂直传播的重要影响因素,可以通过孕前降低男性血清中HBV-DNA的病毒载量来降低HBV垂直传播的几率。
Objective To investigate the effect of hepatitis B virus DNA (HBV-DNA) on the serum levels of HBV-DNA in the father’s serum of hepatitis B virus (HBV) crowd. Methods Fifty-six couples with negative HBsAg, HBsAg and HBV-DNA were enrolled in this study. Cord blood serum was collected from both spouses and neonate, Hepatitis B markers, HBV-DNA load. The newborns HBV-DNA load results as a group basis, comparing the two groups of fathers HBV-DNA load. Results According to the result of neonatal HBV-DNA load, the HBV-DNA load of newborn serum HBV-DNA positive father was significantly higher than that of the father HBV-DNA negative newborn (P <0.01) . Conclusions Male serum HBV-DNA positive and load> 106copies / m L is an important factor influencing the vertical transmission of HBV in infants and young children. It can reduce the vertical transmission of HBV by reducing HBV-DNA viral load in male serum before pregnancy.