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目的:探讨托吡酯单药或添加治疗小儿癫(?)的疗效。方法:对28例癫(?)患儿进行观察,其中全身性发作10例,部分性继发全身性发作4例,复杂部分性发作8例,简单部分性发作4例,婴儿痉挛症2例;应用托吡酯单药或添加治疗,进行自身对照的开放性研究,观察持续治疗6个月的疗效和不良反应。结果:24例(85.7%)发作频率减少≥50%,19例(67.8%)发作减少≥75%,12例(42.8%)发作控制。最常见不良反应为中枢神经系统表现。结论:托吡酯治疗小儿癫(?)安全、有效、耐受性好。
Objective: To investigate the efficacy of topiramate alone or in the treatment of pediatric epilepsy (?). Methods: 28 cases with epilepsy were observed. Among them, there were 10 cases of generalized seizures, 4 cases of partial systemic seizures, 8 cases of complex partial seizures, 4 cases of simple partial seizures, 2 cases of infantile spasms ; Topiramate alone or add treatment, open-source self-control study to observe the efficacy and adverse reactions of 6 months of continuous treatment. Results: Seventy patients (85.7%) had a reduction of seizure frequency of ≥50%, 19 (67.8%) seizure reduction ≥75% and 12 patients (42.8%) seizure control. The most common adverse reactions are central nervous system manifestations. Conclusion: Topiramate is safe, effective and well tolerated in pediatric epilepsy.