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内皮祖细胞是内皮细胞的前体细胞,是一类能够迁移、增殖,并分化为成熟血管内皮细胞的前体细胞,属于干细胞群体,参与人胚胎血管生成及出生后血管新生和内皮损伤后的修复过程,还可在一定条件下分化为心肌细胞。近年来的研究表明其与冠心病发生、发展及治疗的关系密切,为冠心病治疗提供了新思路。本文就内皮祖细胞的生物学特性及其在缺血性心脏病中的临床研究现状予以综述。
Endothelial progenitor cells are the precursors of endothelial cells. They are a group of precursor cells that can migrate, proliferate, and differentiate into mature vascular endothelial cells, belonging to the stem cell population. They are involved in human embryo angiogenesis and postnatal angiogenesis and endothelial injury Repair process, but also under certain conditions differentiate into cardiomyocytes. In recent years, studies have shown that it is closely related to the occurrence, development and treatment of coronary heart disease, which provides a new idea for the treatment of coronary heart disease. This review summarizes the biological characteristics of endothelial progenitor cells and their clinical status in ischemic heart disease.