论文部分内容阅读
目的:研究α-氰基丙烯酸酯医用胶短期肝创面局部反应。方法:试验采用SD雄性大鼠肝表面创伤模型,试验组和对照组分别采用在肝表面创伤部位喷涂医用胶和肝表面创伤部位不做处理方法,于术后5 min、1 d、3 d观察、取材,并进行组织学研究。结果:大体观察:大鼠皮肤切口愈合良好,肝脏手术区大体正常。病理观察:试验组与对照组在术后1 d均有炎症反应,伴有中性粒细胞、淋巴细胞、吞噬细胞渗出,成纤维细胞增生,无坏死发生,但试验组在3 d时炎症较轻,且创伤修复较好。结论:在术后早期,没有发现α-氰基丙烯酸酯医用胶引起局部肝组织坏死,与对照组相比炎症较轻,创伤修复较好。
Objective: To study the local reaction of α-cyanoacrylate medical adhesive on short-term hepatic wound. Methods: The SD rat model of liver trauma was used in the experiment. The experimental group and the control group were treated by spraying the plaster on the surface of the liver and traumatic surface of the liver without treatment at 5 min, 1 d and 3 d after operation , Drawn, and histological studies. Results: Gross observation: The skin incision in rat healed well and the operation area of liver was generally normal. Pathological observation: The experimental group and the control group had inflammatory reaction on the first postoperative day, accompanied by neutrophil, lymphocyte, phagocyte exudation, fibroblast proliferation, no necrosis, but the test group at 3 d of inflammation Light, and wound repair is better. CONCLUSIONS: In the early postoperative period, no local hepatic necrosis was found in medical a-cyanoacrylate gums. Compared with the control group, the inflammation was less severe and the wound repair was better.