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目的:观察三七总皂苷(PNS)对老年性痴呆 (AD)大鼠模型大脑胆碱能神经病理损害的保护作用。方法:以d 半乳糖腹腔注射致亚急性损伤合并鹅膏蕈氨酸 (IBA)损毁双侧大脑Meynert基底核建立AD大鼠动物模型,利用免疫组织化学方法检测大脑切片胆碱乙酰基转移酶 (ChAT)免疫反应活性及阳性神经元数量及形态学改变。结果:PNS能明显减轻由d 半乳糖损害和鹅膏蕈氨酸损毁导致的大脑胆碱能神经元数量减少和ChAT水平降低。结论:PNS对AD大鼠模型大脑胆碱能神经的病理损害具有保护作用。
OBJECTIVE: To observe the protective effect of panax notoginseng saponins (PNS) on cholinergic neuropathological damage in a rat model of Alzheimer’s disease (AD). METHODS: Animal models of AD rats were established by intraperitoneal injection of d galactose to induce subacute lesions with IBA in bilateral basal ganglia of Meynert. Brain choline acetyltransferase was detected by immunohistochemical method. ChAT) immunoreactivity and number of positive neurons and morphological changes. RESULTS: PNS significantly reduced the decrease in the number of cholinergic neurons and the decrease in ChAT levels in the brain caused by damage to d-galactose and destruction of ibotenate. Conclusion: PNS has a protective effect on the pathological damage of cholinergic nerve in AD rat model.