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评价七氟烷麻醉对颅脑创伤(TBI)患者早期预后影响。回顾性收集2015年12月至2019年6月在全身麻醉下行开颅手术的TBI患者的病历资料，年龄≥18岁，性别不限，术中麻醉维持采用丙泊酚或七氟烷。应用多因素回归分析评价丙泊酚麻醉或七氟烷麻醉对TBI患者术后第1、3、7天APACHEⅡ评分的影响。多因素回归分析显示，调整年龄、性别、入院瞳孔反应、入院APACHEⅡ评分、入院CT指标、入院诊断类别、入院血红蛋白浓度、手术方式、术中液体出入量等混杂因素后，七氟烷麻醉与丙泊酚麻醉患者术后第1、3、7天APACHEⅡ评分比较差异无统计学意义(n P>0.05)。综上所述，与丙泊酚麻醉相比，七氟烷麻醉对TBI患者早期预后的影响无差异。n “,”To evaluate the effects of sevoflurane anaesthesia on early prognosis in the patients with traumatic brain injury (TBI). The medical records of TBI patients of both sexes, aged≥18 yr, who underwent craniotomy under general anesthesia from December 2015 to June 2019 and received propofol or sevoflurane for maintaining anesthesia during operation, were retrospectively collected.Multivariate regression analysis was used to evaluate the effects of propofol or sevoflurane anesthesia on APACHEⅡ score on days 1, 3, and 7 after TBI.Multivariate regression analysis showed that after adjusting for confounding factors such as age, gender, pupil response on admission, APACHEⅡ score on admission, computed tomography on admission, category of diagnosis on admission, hemoglobin on admission, type of surgery, and intraoperative fluid intake and output, there was no significant difference in APACHE Ⅱ scores on 1, 3, and 7 days after operation between the patients received sevoflurane anesthesia and those received popofol anesthesia (n P>0.05). In conclusion, the effect of sevoflurane anesthesia on the early prognosis is not different from that of propofol anesthesia in the patients with TBI.n