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咪芬替丁(Mifentidine)是新的H_2-受体拮抗剂,血浆半减期长达10小时,用于治疗十二指肠溃疡。健康志愿者口服咪芬替丁10～20mg,可以减少基础胃酸和五肽胃泌素刺激酸分泌;对十二指肠溃疡病人减少假性食物刺激和胨饮食刺激引起的胃酸分泌也有效。近年来证明,每晚给雷尼替丁300mg一次对急性十二指肠溃疡治疗可促进愈合。本文对两药进行随机双盲临床治疗比较。 60例十二指肠溃疡患者诊断3天内随机分成两组,双盲给药。咪芬替丁每晚20mg,雷尼替丁每晚300mg。服药前后进行
Mifentidine, a new H 2 -receptor antagonist, is used in the treatment of duodenal ulcers for half an hour of plasma half-life. Healthy volunteers orally taking 10 ~ 20mg of imidepine, can reduce the basic gastric acid and pentagastrin to stimulate acid secretion; duodenal ulcer patients reduce pseudo-food stimulation and peptone diet-induced gastric acid secretion is also effective. In recent years it has been shown that administering ranitidine 300 mg once night to acute duodenal ulcer treatment can promote healing. In this paper, two randomized double-blind clinical treatment comparison. 60 cases of duodenal ulcer patients were randomly divided into two groups within 3 days of diagnosis, double-blind administration. Mifentidine 20mg per night, ranitidine 300mg per night. Before and after taking medicine