Effect of continuous positive airway pressure treatment on serum adiponectin level and mean arterial

来源 :中华医学杂志(英文版) | 被引量 : 0次 | 上传用户:thardway
下载到本地 , 更方便阅读
声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架
论文部分内容阅读
Background Recent research suggested that obstructive sleep apnea syndrome (OSAS) might be independently associated with hypoadiponectinemia, which was linked to some complications of OSAS, such as hypertension, diabetes,etc. This study was conducted to investigate the effect of continuous positive airway pressure (CPAP) treatment on changes of both serum adiponectin levels and mean arterial pressure and their possible links in male OSAS patients.Methods Twenty-three adult male patients with moderate-to-severe OSAS but without obesity, coronary heart disease and diabetes were recruited. Their blood sampleswere collected and moming mean arterial pressure (MAP) was measured before CPAP treatment and on day 3, 7, 14 of CPAP treatment respectively. The serum adiponectin concentration was tested with radioimmunoassay.Results Compared with the serum adiponectin level before CPAP treatment, no significant change was found in OSAS patients on day 3 and day 7 of CPAP treatment (P>0.05). It was not until day 14 of CPAP treatment did a significant elevation in serum adiponectin level occur (P<0.01). Meanwhile, the MAP showed no statistically significant difference among its levels before CPAP, on day 3 and day 7 of CPAP treatment (P>0.05). However, on day 14 of CPAP treatment,a significantly lower MAP than that obtained before treatment was observed (P<0.05).Conclusions CPAP treatment can gradually reverse hypoadiponectinemia and reduce MAP in OSAS patients.Hypoadiponectinemia might be involved in the pathogenesis of OSAS-mediated hypertension.
其他文献
(本刊讯)由中国造纸协会生活用纸专业委员会主办的生活用纸年会是行业每年最重要的技术交流和贸易活动,经过20多年的发展,生活用纸年会已实现规模化、品牌化、国际化,成为生
叙述了功能纸的种类及各种功能纸的应用开发情况
期刊
随着中国经济的发展,办公楼、工厂以及大型公共建筑的高耗能问题日益突出.数据显示,如果不采取有力措施,到2020年中国建筑能耗将是现在的3倍以上,届时能源紧张问题将更加严峻
本文就漂白混合木浆在中性松香胶AS39的施胶过程中的一些湿部化学现象进行了初步的探讨,实验结果表明:(1)填料的加入显著降低了细小组分的留着率(2)流体剪切力能显著影响不同
目的对生脉辅半饱合量西地兰治疗婴幼儿肺炎合并心力衰竭进行临床观察研究。方法选择2002年10月至2006年2月90例肺炎心衰住院患儿,随机分为治疗组(生脉辅半饱合量西地兰)、全
目的:研究中药地癈中的有效成分.方法:溶剂萃取及各种色谱技术分离纯化,经UV,IR,1H-NMR,13C-NMR,MS以及化学方法鉴定了它们的结构.结果:分离得到5种单体化合物,分别是正十六
文章介绍了利用稳定塘和苇田系统,对碱法稻草制浆造纸废水作深度处理,并实行封闭循环的效果,对该方法的适应条件等问题进行了论述.
本文简要介绍了造纸白水的回用和循环以及白水的处理技术最新进展.
目的 探讨帕罗西汀合并丙戊酸钠治疗伴有焦虑的抑郁症患者的疗效及安全性.方法 对符合人组标准的80例患者随机分为两组,实验组采用帕罗西汀合并丙戊酸钠治疗,对照组单独采用