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应用全细胞膜片钳技术，研究巴氯芬（baclofen）对新鲜分离的大鼠DRG神经元的作用。结果发现：GABAB受体选择性激动剂baclofen（10－5和10－4mol／L）对蝇蕈醇（muscimol）（10－5mol／L）和异四氢烟酸（isoguvacine）（5×10－5mol／L）-激活电流有抑制作用，并呈浓度依赖性。并对baclofen抑制GABAA选择性受体激动剂muscimol-和isoguvacine-激活电流反应可能的胞内转导机制进行了讨论。
Whole cell patch clamp techniques were used to study the effect of baclofen on freshly isolated rat DRG neurons. As a result, it was found that the effects of baclofen (10-5 and 10-4 mol / L) on muscimol (10-5 mol / L) and isoguvacine (5x10- 5mol / L) - activation current inhibition, and in a concentration-dependent manner. And discussed the possible intracellular transduction mechanism of baclofen inhibiting the GABAA selective receptor agonists muscimol- and isoguvacine-activated currents.