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目的探讨2型糖尿病患者腹胀与小肠细菌过度生长(SIBO)的关系。方法将96例2型糖尿病患者分为血糖正常且无腹胀组、血糖正常并腹胀组、血糖升高无腹胀组、血糖升高并腹胀4组,通过乳果糖氢呼气试验分别检测其SIBO情况及口盲时间,并与健康对照组进行组间比较分析。结果血糖升高并腹胀组患者的SIBO阳性率较其他组患者明显增高,差异有统计学意义。腹胀组SIBO阳性率与健康对照组比较有统计学差异(P<0.05),4组患者口盲时间与健康对照组比较均有统计学意义(P<0.01)。结论 2型糖尿病合并腹胀患者易发生SIBO,与口盲时间延长相关,其可能是腹胀发生的重要发病机制。
Objective To investigate the relationship between abdominal distension and intestinal bacterial overgrowth (SIBO) in type 2 diabetic patients. Methods 96 patients with type 2 diabetes mellitus were divided into four groups: normal blood glucose without abdominal distension group, normal blood sugar and abdominal distension group, hyperglycemia without abdominal distension group, elevated blood sugar and abdominal distension. The SIBO status was detected by lactulose hydrogen breath test And oral blind time, and compared with the healthy control group between groups. Results The positive rate of SIBO in patients with elevated blood glucose and abdominal distension was significantly higher than that in other groups, the difference was statistically significant. The positive rate of SIBO in abdominal distension group was significantly higher than that in healthy control group (P <0.05). The time of oral blindness in the four groups was statistically significant (P <0.01) compared with healthy control group. Conclusions SIBO is easy to occur in patients with type 2 diabetes mellitus and abdominal distension, which is related to the prolongation of oral blindness, which may be an important pathogenesis of abdominal distension.