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目的探讨低浓度医用臭氧直肠灌注治疗子宫颈癌晚期放射性直肠损伤的临床疗效及不良反应。方法对49例子宫颈癌放射性直肠损伤患者先将细导气软管插入肛门5~7 cm,再将20μg·mL-1医用臭氧(医用纯氧经过臭氧发生器制备)50 mL·次-1缓慢灌注到直肠,保留10 min不排气。3次·周-1,2周为1疗程,共治疗2个疗程。同时采用消炎、止血、解痉、维生素C、维生素B族及静脉输液等治疗。结果 49例患者治疗后损伤程度为Ⅰ级的治愈率、总有效率与损伤程度为Ⅱ级比较差异均无统计学意义(61.3%、100.0%vs 55.6%、88.9%,均P>0.05)。结论低浓度医用臭氧直肠灌注治疗子宫颈癌晚期放射性直肠损伤有较好的疗效,无明显不良反应。
Objective To investigate the clinical efficacy and adverse reactions of low-concentration medical ozone rectal perfusion in the treatment of advanced radiation-induced rectal injury of cervical cancer. Methods 49 cases of cervical cancer patients with radioactive rectal injury before the first thin air hose inserted into the anus 5 ~ 7 cm, and then 20μg · mL-1 medical ozone (medical oxygen prepared by the ozone generator) 50 mL · times -1 slowly Perfused into the rectum for 10 min without degassing. 3 times a week -1,2 weeks for a course of treatment, a total of 2 courses of treatment. At the same time using anti-inflammatory, bleeding, antispasmodic, vitamin C, vitamin B and intravenous fluids and other treatment. Results The cure rate of grade Ⅰ in 49 patients was no significant difference between the two groups (61.3%, 100.0% vs 55.6%, 88.9%, all P> 0.05). Conclusion Low-dose medical ozone rectal perfusion treatment of advanced cervical cancer radioactive rectal injury has a good effect, no significant adverse reactions.