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目的:探讨超敏C反应蛋白(hs-CRP)水平变化与出血性脑卒中的关系。方法:收集盐城市第一人民医院2009年住院的出血性脑卒中患者149例,同时选择同地区参与健康调查的社区人群作为对照,按同性别、同年龄(±2岁)进行1∶2匹配,共选择了298例非脑卒中对象作为对照。采用统一的流行病学调查表收集基本资料、个人疾病史,同时检测血压和血糖、血脂和hs-CRP等生化指标,应用Cox回归模型进行分析。结果:病例组hs-CRP水平显著高于对照组(P<0.001);校正高血压史、糖尿病史、血糖和血脂升高等危险因素后,hs-CRP每升高1 mg/L的OR值(95%CI)为1.386(1.230～1.563),P<0.001;而hs-CRP升高(≥3 mg/L)的OR值(95%CI)为6.599(3.141～13.867),P<0.001。进一步按性别分层分析结果显示,男性hs-CRP升高(≥3 mg/L)者脑出血的患病风险高于女性,OR值(95%CI)分别为8.675(3.206～23.469)、3.836(1.106～13.308),P值分别为<0.001、<0.05。结论:hs-CRP升高与出血性脑卒中存在显著关联,且男女hs-CRP升高与出血性脑卒中的关联存在差异。
Objective: To investigate the relationship between hs-CRP levels and hemorrhagic stroke. Methods: A total of 149 patients with hemorrhagic stroke admitted to the First People’s Hospital of Yancheng in 2009 were selected. At the same time, community residents who participated in the health survey in the same area were selected as the control and matched with the same sex (± 2 years old) for 1: 2 matching A total of 298 non-stroke subjects were selected as controls. A uniform epidemiological questionnaire was used to collect basic information and personal disease history. Blood pressure, blood glucose, blood lipid, hs-CRP and other biochemical parameters were also detected. Cox regression model was used to analyze the biochemical indicators. Results: The hs-CRP level in case group was significantly higher than that in control group (P <0.001). After adjusting for the risk factors such as history of hypertension, history of diabetes mellitus, hyperglycemia and hyperlipidemia, the OR of every 1 mg / L hs- 95% CI) was 1.386 (1.230-1.563), P <0.001; OR of 95% CI was 6.599 (3.141 ~ 13.867), P <0.001 for patients with elevated hs-CRP≥3 mg / L. Further stratified by sex, the risk of ICH in men with elevated hs-CRP (≥3 mg / L) was higher than that in women (OR = 8.675, 3.206-23.469, 3.836 (1.106 ~ 13.308), P values were <0.001, <0.05 respectively. Conclusions: There is a significant correlation between the increase of hs-CRP and hemorrhagic stroke, and there is a significant difference between the increase of hs-CRP in men and women and hemorrhagic stroke.