Gattermann-Koch 反应是实验室制备对-甲基苯甲醛(p-TAL)的常用方法。通常认为,氯化亚铜在反应体系中是一种必要的助剂,否则,常压下甲苯羰基化就无法进行。1979年,голубев曾不用氯化亚铜和氯化氢为助剂进行 Gattermann-Koch 反应。一年后,Toniolo 报道了以三氯化铝为催化剂,氯化亚铜-三苯基膦络合物为助剂的芳香烃羰基 The Gattermann-Koch reaction is a commonly used method for laboratory preparation of p-tolualdehyde (p-TAL). It is generally accepted that cuprous chloride is an essential additive in the reaction system otherwise toluene carbonylation will not proceed at atmospheric pressure. In 1979, голубев used Gattermann-Koch reaction without cuprous chloride and hydrogen chloride as auxiliaries. A year later, Toniolo reported on the use of aluminum trichloride as a catalyst, cuprous chloride - triphenylphosphine complex as an aromatic hydrocarbon carbonyl