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目的 探讨 2型糖尿病肾病患者 (DN)血清细胞粘附分子变化及其与氧化应激的关系。 方法 检测DN患者血清可溶性细胞间粘附分子 1(sICAM 1)、可溶性血管细胞粘附分子 1(sVCAM 1)、血清丙二醛 (MDA)含量和超氧化物歧化酶 (SOD)活性。 结果 早期DN及DN患者血清sVCAM 1水平〔分别为 (1 75± 0 48)、(1 91± 0 2 7)mg/L〕明显高于对照组〔(1 6 7± 0 72 )mg/L ,P <0 0 5和0 0 1〕 ,DN组明显高于单纯糖尿病 (DM)组〔(1 5 8± 0 39)mg/L ,P <0 0 5〕 ;DM组、早期DN组和DN组患者血清sICAM 1〔分别为 (75 6 0 0± 12 5 47)、(80 2 2 1± 12 4 81)、(897 6 0± 10 5 80 ) μg/L〕明显高于对照组〔(5 82 6 4± 10 2 73) μg/L ,P <0 0 0 1〕 ,其中DN组明显高于单纯DM组和早期DN组 (分别P <0 0 1和<0 0 5 ) ;单纯DM组、早期DN组和DN组患者血清SOD活性〔分别为 (86 5 9± 13 85 )、(85 6 9±11 32 )、(71 73± 16 35 )NU/L〕显著性低于对照组〔(92 73± 11 2 5 )NU/ml,P <0 0 1〕 ,MDA含量〔分别为(3 99± 1 36 )、(4 2 6± 1 95 )、(6 5 0± 2 98)nmol/ml〕显著性高于对照组〔(3 72± 0 5 7)nmol/ml,P <0 0 1〕。DM患者血清sVCAM 1与sICAM 1、收缩压、尿素氮 (BUN)和肌酐 (Cr)呈正相?
Objective To investigate the changes of serum cell adhesion molecules (DNs) and its relationship with oxidative stress in type 2 diabetic nephropathy patients. Methods Serum levels of soluble intercellular adhesion molecule 1 (sICAM 1), soluble vascular cell adhesion molecule 1 (sVCAM 1), serum malondialdehyde (MDA) and superoxide dismutase (SOD) were detected in patients with DN. Results Serum levels of sVCAM1 in patients with early DN and DN [(75 ± 0 48, (91 1 ± 0 2 7) mg / L, respectively] were significantly higher than those in the control group [(1 6 7 ± 0 72) mg / L , P <0 05 and 0 0 1], DN group was significantly higher than that of DM group [(158 ± 0 39) mg / L, P 0 05); DM group, early DN group and Serum levels of sICAM 1 [75 6 0 0 ± 12 5 47, (80 2 2 ± 12 4 81), (897 6 0 ± 10 5 80) μg / L, respectively] in DN group were significantly higher than those in control group [ (5 82 6 4 ± 10 2 73) μg / L, P 0 01). The DN group was significantly higher than that of DM group and DN group (P <0.01 and <0.05, respectively) Serum SOD activity (86 59 ± 13 85, 85 69 ± 11 32, (71 73 ± 16 35) NU / L, respectively) in DM group, early DN group and DN group was significantly lower than that in control group (92 73 ± 11 2 5) NU / ml, P 0 01), MDA content [(3 99 ± 1 36), (42 6 ± 1 95), (6 5 0 ± 2 98) ) nmol / ml] was significantly higher than that in the control group [(372 ± 0 57) nmol / ml, P <0.01). DM patients with serum sVCAM 1 and sICAM 1, systolic blood pressure, urea nitrogen (BUN) and creatinine (Cr) was positive?