吡唑酮类解热镇痛药氨基比林、安乃近等可引起严重的毒性反应,如粒细胞减少症、再生障碍性贫血、严重过敏反应和致癌等。八十年代解热镇痛药物主要改用毒性小使用安全的对乙酰氨基酚(扑热息痛)替代毒性较大的吡唑酮类药物,且主张制剂单方化,因为大量临床研究表明,两种以上 Pyrazolidone antipyretic analgesics such as aminopyrine and analgin can cause serious toxic reactions such as neutropenia, aplastic anemia, severe allergic reaction and carcinogenesis. In the 1980s, antipyretics and analgesics were mainly used instead of the less toxic ones. The safe use of acetaminophen (paracetamol) was substituted for the more toxic pyrazolones and the formulation was unilaterally advocated because a large number of clinical studies showed that two or more