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朊病毒是一类可传递的蛋白质感染颗粒,似乎仅仅由一种修饰后的蛋白PrP~(Sc)构成。PrP~(Sc)由正常细胞蛋白prp~(c)通过翻译后加工、发生构象变化而形成。牛海绵状脑病和人Creutzfeldt-Jacob病(CJD)是朊病毒引起的最著名的中枢神经系统变性疾病。CJD有散发性、家族性、传染性、医原性等。有证据表明牛朊病毒已传递至人类导致新的变异性CJD。针对朊病毒病独持的致病机制可得出若干防冶策略。
Prions are a class of transmissible protein-infected particles that appear to consist of only one modified protein, PrP ~ (Sc). PrP ~ (Sc) by the normal cellular protein prp ~ (c) through post-translational processing, the formation of conformational changes. Bovine spongiform encephalopathy and Creutzfeldt-Jacob disease (CJD) are the most prevalent central nervous system degenerative diseases caused by prions. CJD sporadic, familial, infectious, medical and so on. There is evidence that bovine prion virus has been delivered to humans causing new variability in CJD. Prophylaxis of prion diseases can lead to a number of proprietary strategies.