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目的比较胺碘酮与洋地黄治疗快速心房颤动的疗效与安全性。方法92例房颤患者,随机分为胺碘酮组与洋地黄组。胺碘酮组首剂量给予3mg/kg静脉推注,其后0.8～1mg/min维持,24h总剂量700～1000mg。洋地黄组:近1周未用地戈辛者,予毛花甙C0.2mg静脉推注,30min无效者追加0.2mg,30min仍无效再追加0.2mg,总剂量不大于1.2mg。近1周服用地戈辛者,开始予毛花甙C0.2mg静脉推注,30min无效者追加0.2mg,30min仍无效再追加0.2mg,总剂量不大于0.6mg。结果两组比较,胺碘酮组、洋地黄组控制心室率总有效率分别为83%、61%,心室率平均下降幅度为35%和21%,平均起效时间分别为(14±10)min、(30±5)min。两组均有1例出现症状性低血压。结论胺碘酮能安全、有效控制房颤心室率。
Objective To compare the efficacy and safety of amiodarone and digitalis in the treatment of rapid atrial fibrillation. Methods 92 patients with atrial fibrillation were randomly divided into amiodarone group and digitalis group. The first dose of amiodarone given intravenous injection of 3mg / kg, followed by 0.8 ~ 1mg / min maintenance, 24h total dose of 700 ~ 1000mg. Digitalis group: nearly 1 week did not use Geoxin, to Ceratoside C0.2mg intravenous injection, 30min invalid additional 0.2mg, 30min is still invalid and then add 0.2mg, the total dose of not more than 1.2mg. Nearly one week taking Geosin who began to intravenous injection of Cefoperazone C0.2mg, 30min invalid additional 0.2mg, 30min still invalid and then add 0.2mg, the total dose of not more than 0.6mg. Results The total effective rate of ventricular rate control in amiodarone group and digitalis group was 83% and 61% respectively, and the average decrease rate of ventricular rate was 35% and 21% respectively. The average effective time was (14 ± 10) min, (30 ± 5) min. Symptomatic hypotension occurred in 1 patient in both groups. Conclusions Amiodarone can control the ventricular rate of atrial fibrillation safely and effectively.