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钩藤治疗高血压具有稳定而持久的疗效,其有效部位为以钩藤碱(Rhynchophylline)为主成分的生物碱。钩藤总碱经天津卫生局鉴定,已交付临床使用。本文拟探讨作为制剂原料的有效提取物的提取方法,作者以前曾进行过一些探索,在这里作进一步讨论。提取方法主要以总生物碱的提取率为依据,并考察了钩藤碱(氧化吲哚类生物碱)的异构化等问题,最后对有效提取物进行讨论和评价,本文所用原料为Uncaria rhynchophylla(Miq.)Jacks.系一批购得。
Uncaria Hung has a stable and long-lasting effect in the treatment of hypertension, and its effective part is an alkaloid with Rhynchophylline as its main component. Alkaloids from Rhynchophylla have been identified by the Tianjin Health Bureau and have been delivered for clinical use. This article intends to explore the extraction method for effective extracts as a raw material for preparations. The authors have conducted some explorations before and are further discussed here. The extraction method was based on the extraction rate of total alkaloids, and the isomerization of rhynchophylline (anthraquinone alkaloids) was investigated. Finally, effective extracts were discussed and evaluated. The raw material used in this study was Uncaria rhynchophylla. (Miq.) Jacks. Purchased in batches.