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目的探讨青年突发迷走神经性晕厥的发病机制与外周血管内皮功能的关系。方法选择经直立倾斜试验诊断为迷走神经性晕厥的36例青年患者为晕厥组,30例直立倾斜试验除外迷走神经性晕厥的患者为对照组,利用彩色多普勒超声心动图仪对两组患者进行血管内皮功能测定。结果两组患者的年龄、性别和吸烟患者的比例无明显差别,晕厥组的血管内皮依赖性舒张功能及血管内皮非依赖性舒张功能较对照组增强:(9.08±4.01)%对(6.32±3.10)%,P<0.05;(15.26±7.69)%对(11.82±6.30)%,P<0.05。结论外周血管内皮功能异常可能是青年突发迷走神经晕厥的机制之一。
Objective To investigate the relationship between the pathogenesis of peripheral vagal syncope and peripheral vascular endothelial function in young patients. Methods Thirty-six young patients diagnosed as having vagal syncope by the upright tilt test were in the syncope group. Thirty patients except the upright tilt test except for vagal syncope were used as the control group. Color Doppler echocardiography was performed on the two groups of patients Endothelial function assay. Results There was no significant difference in the age, sex and smoking prevalence between the two groups. The endothelium-dependent vasodilatation and endothelium-independent vasodilatation in the syncope group were significantly higher than those in the control group (9.08 ± 4.01% vs 6.32 ± 3.10 )%, P <0.05; (15.26 ± 7.69)% vs (11.82 ± 6.30)%, P <0.05. Conclusion Peripheral vascular endothelial dysfunction may be one of the mechanisms of sudden vagal syncope in young people.