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目的探讨阜新部分地区乙型肝炎病毒(HBV)的感染同非霍奇金淋巴瘤(NHL)的关系。方法回顾性调查2006年至2012年在阜新矿业(集团)有限责任公司总医院、阜矿集团平安医院及阜矿集团城南医院住院的150例NHL患者(NHL组)的初诊及4疗程化疗的临床资料,并与其他恶性肿瘤(除原发性肝癌)组及体检组各150例对象的乙肝表面抗原(HBs Ag)及肝功能情况进行对比。结果 NHL组的HBs Ag阳性率分别与其他恶性肿瘤组、体检组(24.0%vs 12.0%,P<0.01;24.0%vs 8.0%,P<0.01)比较,差异具有统计学意义;其他恶性肿瘤组与体检组之间的HBs Ag阳性率比较,差异无统计学意义(12.0%vs 8.0%,P>0.05)。NHL组化疗后肝功能损伤者13例,肝功能正常者23例,前者HBs Ag阳性率高于后者(38.2%vs 19.8%,P<0.05)。结论 HBV感染可能增加NHL的发病风险及患者化疗后肝功能受损的发生率。
Objective To investigate the relationship between hepatitis B virus (HBV) infection and non-Hodgkin’s lymphoma (NHL) in parts of Fuxin. Methods A retrospective survey of 150 NHL patients (NHL group) hospitalized in Fuxin Mining (Group) Co., Ltd. General Hospital, Fu Mine Group Ping An Hospital and Fudan Group Cheng Nan Hospital between 2006 and 2012 was conducted and the clinical course of 4 cycles of chemotherapy Data, and compared with other HBsAg and liver function in 150 cases of other malignant tumors (except primary liver cancer) and physical examination group. Results The positive rate of HBsAg in NHL group was significantly higher than that in other malignant tumor group and the control group (24.0% vs 12.0%, P <0.01; 24.0% vs 8.0%, P <0.01) There was no significant difference in the positive rate of HBsAg between the two groups (12.0% vs 8.0%, P> 0.05). The NHL group had 13 cases of liver damage after chemotherapy and 23 cases of normal liver function. The positive rate of HBsAg in the former was higher than that in the latter (38.2% vs 19.8%, P <0.05). Conclusion HBV infection may increase the risk of NHL and the incidence of liver dysfunction in patients after chemotherapy.