硝酸酯类药物是治疗心绞痛的古老药物,至今已有130余年历史,但仍然是基础治疗药,而且对各种类型的心绞痛都有效。根据临床观察,连续服药48～72小时可很快出现耐药性,因此,我们必须对它的耐药性采取良好的对策。 硝酸酯类进入平滑肌或通过细胞外途径,解离为无机硝酸盐并最终形成氮氧化物,此解离需要有 Nitrates are ancient medicines for the treatment of angina and have been in existence for more than 130 years now, but they are still the basic remedies and effective for all types of angina. According to clinical observation, 48 to 72 hours of continuous medication can quickly appear resistance, therefore, we must take a good response to its resistance. Nitrates enter the smooth muscle or through extracellular pathways, dissociate into inorganic nitrates and eventually form nitrogen oxides, and this dissociation requires