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目的:研究去白细胞红细胞悬液在弥散性血管内凝血(DIC)治疗中的作用。方法:用去白细胞红细胞悬液和新鲜冰冻血浆联合输注进行临床观察,并与新鲜全血的临床效果进行比较,同时检测当天和储存3d的新鲜全血以及7d内去白细胞红细胞悬液中组织型纤溶酶原激活物(t-PA)的活性,以旁证去白细胞红细胞悬液在DIC治疗中的作用。结果:当天和储存3d的新鲜全血,以及7d内去白细胞红细胞悬液中t-PA的活性,三者间t-PA活性差异无统计学意义。用7d内去白细胞红细胞悬液和新鲜冰冻血浆代替当天新鲜全血抢救DIC患者可取得同等效果。结论:7d内去白细胞红细胞悬液中t-PA的活性与当天新鲜全血差异无统计学意义,抢救DIC时不必要强调输注新鲜全血,只要合理输注成分血,效果等同于新鲜全血。
Objective: To study the role of leukocyte-depleted erythrocyte suspension in the treatment of disseminated intravascular coagulation (DIC). Methods: The clinical observation of combination of leukocyte-depleted erythrocyte suspension and fresh frozen plasma was performed and compared with the clinical effect of fresh whole blood. Meanwhile, fresh whole blood on day and stored for 3 days and the tissue of leukocyte suspension in 7 days Type plasminogen activator (t-PA) activity in order to bypass evidence of leukocyte erythrocyte suspension in the role of DIC treatment. Results: There was no significant difference in t-PA activity between the fresh whole blood stored on the day and 3d, and the activity of t-PA in the leukocyte suspension on day 7. With 7d within the leukocyte red blood cell suspension and fresh frozen plasma instead of the same day fresh whole blood rescue DIC patients can achieve the same effect. CONCLUSION: The activity of t-PA in leukocyte erythrocyte suspension on the 7th day was not significantly different from the fresh whole blood on the same day. It is unnecessary to emphasize the infusion of fresh whole blood when rescuing DIC. As long as the infusion of blood is reasonable, the effect is equivalent to freshness blood.