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目的观察脑栓通胶囊对动脉硬化性脑梗死患者血管弹性功能的影响。方法入选动脉硬化性脑梗死病例78例,分为治疗组43例和对照组35例,对照组采取口服抗血小板药物加康复锻炼治疗,治疗组在对照组治疗基础上加用脑栓通胶囊,治疗6月后观察患者的血液流变学、肱-踝脉搏波传导速度(PWV)、踝臂指数(ABI)和颈动脉内中膜厚度(IMT)变化。结果两组血液流变学、ABI及PWV治疗后均有改善,且治疗组优于对照组(P<0.05),而两组颈动脉IMT差异无显著统计学意义(P>0.05)。结论脑栓通胶囊能改善动脉硬化性脑梗死患者的血管僵硬度,ABI和PWV可作为反映血管弹性功能较灵敏的指标。
Objective To observe the effect of Naoshuantong capsule on the vascular elasticity of patients with arteriosclerotic cerebral infarction. Methods A total of 78 patients with arteriosclerotic cerebral infarction were enrolled and divided into treatment group (n = 43) and control group (n = 35). The control group was given oral antiplatelet drugs plus rehabilitation exercise. The treatment group was given Naoshuantong capsules on the basis of the control group, After 6 months of treatment, the changes of hemorheology, brachial-ankle pulse wave velocity (PWV), ankle-brachial index (ABI) and carotid intima-media thickness (IMT) were observed. Results The hemorheology, ABI and PWV treatment improved in both groups, and the treatment group was better than the control group (P <0.05). There was no significant difference in carotid IMT between the two groups (P> 0.05). Conclusion Naosituong Capsule can improve the vascular stiffness of patients with arteriosclerotic cerebral infarction. ABI and PWV can be used as a more sensitive indicator of vascular elasticity.