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目的探讨肝细胞性肝癌(hepatocellu lar carc inom a,HCC)中肥大细胞与肿瘤微血管密度的关系。方法将40例HCC石蜡标本分为高侵袭转移组(14例)和低侵袭转移组(26例)。采用免疫组化SP法,检测肥大细胞计数(m ast cell count,MCC)与微血管密度(m icrovessel density,MVD),统计分析两者的相关性。结果HCC高侵袭转移组的MCC(18.7±3.2)个/Hp、MVD(41.8±9.4)与低侵袭转移组的MCC(11.4±4.6)个/Hp、MVD(27.3±6.5)比较,有显著性差异(P<0.05)及非常显著性差异(P<0.01)。HCC中MCC与MVD之间存在正相关。结论肥大细胞(m ast cell,MC)可能有刺激HCC肿瘤血管新生的作用。
Objective To investigate the relationship between mast cells and tumor microvessel density in hepatocellular carcinoma (HCC). Methods Forty HCC paraffin specimens were divided into high invasion metastasis group (14 cases) and low invasion metastasis group (26 cases). The immunohistochemical SP method was used to detect the number of m ast cell count (MCC) and m icrovessel density (MVD), and the correlation between the two was statistically analyzed. Results MCC (18.7 ± 3.2) / Hp, MVD (41.8 ± 9.4) in HCC group with high invasiveness and metastasis were significantly higher than those in low invasion group (11.4 ± 4.6) / Hp and MVD (27.3 ± 6.5) Difference (P <0.05) and very significant difference (P <0.01). There is a positive correlation between MCC and MVD in HCC. Conclusion Mast cells (MCs) may stimulate the angiogenesis of HCC tumor.