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目的探讨腺性膀胱炎电切术后应用吡柔比星膀胱内灌注化疗预防复发的疗效。方法84例病理证实的腺性膀胱炎患者,44例经尿道电切术后行吡柔比星膀胱内灌注(A组),40例仅单纯电切治疗(B组),比较两组患者术后复发率及观察吡柔比星膀胱内灌注副反应。结果随访3～54个月,平均36个月,A组6例复发,B组13例复发,两组总复发率比较差异有统计学意义(P<0.05)。吡柔比星主要副作用为尿频、尿急、尿痛等膀胱刺激症状。结论腺性膀胱炎电切术后应用吡柔比星膀胱内灌注能明显减少腺性膀胱炎电切术后复发,且副反应少,安全性较高。
Objective To investigate the efficacy of intravesical instillation chemotherapy of pirarubicin to prevent recurrence after gastrectomy of glandular cystitis. Methods Eighty-four patients with pathologically confirmed cystitis glandularis, 44 patients undergoing transurethral resection of bladder with intravesical instillation of pirarubicin (group A) and 40 patients treated with simple electrotomy (group B) Recurrence rate and observe intravesical perfusion side effects of pirarubicin. Results The patients were followed up for 3 to 54 months with an average of 36 months. Recurrence occurred in 6 patients in group A and 13 patients in group B. The total recurrence rate was significantly different between the two groups (P <0.05). Pirarubicin main side effects of urinary frequency, urgency, dysuria and other bladder irritation. Conclusion The application of pirarubicin intravesical instillation after gastrectomy for cystitis glandularis can significantly reduce the recurrence of glandular cystitis after resection with less side effects and higher safety.