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细菌的群体感应系统控制着细菌生物膜的形成、毒力因子的表达和耐药性的产生等过程,群体感应抑制剂可在一定程度上减弱细菌的致病性和耐药性,给临床感染性疾病的防治带来福音。中药群体感应抑制剂通过抑制细菌信号分子的合成、促进信号分子的降解以及抑制信号分子与受体蛋白相结合,对细菌群体感应系统起到抑制作用。文章综述了中药对革兰氏阴性细菌和革兰氏阳性细菌群体感应系统的抑制作用,以期为新型抗菌药物的筛选提供新的思路。
The bacterial population sensing system controls the formation of bacterial biofilms, the expression of virulence factors and the generation of drug resistance, etc. Group induction inhibitors can reduce the pathogenicity and drug resistance of bacteria to a certain extent, and give clinical infection Prevention and treatment of sexual diseases bring the gospel. Herbal quorum sensing inhibitors can inhibit the bacterial population sensing system by inhibiting the synthesis of bacterial signaling molecules, promoting the degradation of signal molecules and inhibiting the combination of signaling molecules and receptor proteins. This article reviews the inhibitory effect of traditional Chinese medicine on gram-negative bacteria and gram-positive bacterial population sensing system, with a view to provide new ideas for the screening of new antibacterial drugs.