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The biofiltering capacity,distribution pattems and degradation of the antimicrobial sulfamethazine (SMT) by halophyte Chenopodium quinoa under hydroponic conditions and its further biodegradation through anaerobic digestion were evaluated.C.quinoa was cultivated for a complete life cycle under different concentrations of SMT (0,2 and 5 mg/L) and sodium chloride (0 and 15 g/L).C.quinoa is able to uptake and partially degrade SMT.The higher the SMT concentration in the culture medium,the higher the SMT content in the plant tissue.SMT has different distribution patts within the plant organs,and no SMT is found in the seeds.Dry crop residues containing SMT have a great potential to produce methane through anaerobic digestion and,in addition,SMT is further biodegraded.The highest specific methane yields are obtained using crop residues of the plants cultivated in the presence of salt and SMT with concentrations between 0 and 2 mg/L.