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目的:建立无创性测定上气道临界闭合压（Pcrit）评估睡眠时上气道塌陷性的方法。方法:应用具有自主知识产权的无创正/负压（CPAP/CPNP）呼吸机，测量19例不伴阻塞性睡眠呼吸暂停综合征（OSAS）正常人非快速动眼睡眠Ⅱ期（N2）的Pcrit，即直接测量法获得Pcrit；根据鼻内压和所对应的最大吸气流量（Vn imax），绘出压力-流量线性关系曲线，间接推出Vn imax为零时的压力，即间接测量法获得Pcrit。对比两种方法的相关性。n 结果:受试者的Pcrit直接测量值为（-7.02±2.74）cmHn 2O（1 cmHn 2O=0.098 kPa），间接测量值为（-7.26±2.96）cmHn 2O，两者相比差异无统计学意义（n t=1.667，n P>0.05），呈高度相关（n r=0.986，n P=0.000）。Bland-Altman分析，两种测量结果差值的均数为（0.24±0.53）cmHn 2O，95%n CI为（-0.80，1.27）cmHn 2O，除1例外，其余均分布在一致性界限内。n 结论:Pcrit直接和间接测量法具有较好的一致性，可以评估上气道的塌陷性。“,”Objective:To establish a noninvasive method for measuring upper airway critical closing pressure (Pcrit), so as to evaluate collapsibility of the upper airway during sleep.Methods:Pcrit was determined through the use of a noninvasive positive/negative pressure (CPAP/CPNP) ventilator(with independent intellectual property rights) during stageⅡ of non-rapid eye movement sleep. For the direct measurement, Pcrit was the pressure below which the upper airway occluded. For the indirect measurement, nasal pressure was plotted against maximum inspiratory flow (Vn imax), and linear regression was used to interpolate the pressure (i.e., Pcrit) at which zero flow occurred. Pcrit was attained from 19 subjects without obstructive sleep apnea syndrome(OSAS), and the correlation between direct and indirect measurement methods was analyzed.n Results:Directly measured and indirectly measured Pcrit showed no significant difference [(-7.02±2.74 n vs (-7.26±2.96) cmHn 2O, 1 cmHn 2O=0.098 kPa; n t=1.667, n P>0.05] and had a highly significant correlation (n r=0.986, n P=0.000). Bland-Altman analysis revealed that the mean between-method difference was (0.24±0.53) cmHn 2O, and 95% limits of agreement ranged from -0.80 to 1.27 cmHn 2O, and all points except one were within limits of agreement.n Conclusion:Pcrit derived from the direct and indirect measurement methods does not differ, and both methods could be used for evaluating the upper airway collapsibility.