Fascin-2基因属于Fascins家族，其蛋白质编码产物是一组结构独特、进化保守的肌动蛋白交联蛋白，位于细胞膜皱襞、微棘突起及应力纤维，控制肌动蛋白细丝平行、有序、紧密排列与聚集。近年来研究发现，Fascin-2基因与连接以肌动蛋白为基本成分的纤毛质膜有密切联系，从而在感光器圆盘以及毛细胞静纤毛的形成中起重要作用，Fascin-2突变可引起原发性视网膜色素变性及渐进性的听力减退。就Fascin-2基因的研究进展进行阐述。“,”Fascin-2 gene,an actin cross-linking protein found in membrane ruffles,microspikes,and stress fibers,con-trols the parallel,sequential,and tight alignment and aggregation of actin filaments.Recent researches have found that Fascin-2 gene is associated with the cilia of plasma membrane,whose basic composition is actin;Fascin-2 gene plays an important role in the formation of photoreceptor disk and stereocilia;the mutation of Fascin-2 gene may cause progres-sive retinitis pigmentosa and hearing loss.This paper will elucidate the latest research progress on Fascin-2 gene.