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目的探讨纳洛酮联合无创正压通气治疗慢性阻塞性肺疾病合并呼吸衰竭的临床疗效。方法将我院收治的60例慢性阻塞性肺疾病合并呼吸衰竭患者随机分为治疗组和对照组各30例,治疗组给予纳洛酮联合无创正压通气治疗,对照组仅给予纳洛酮治疗,比较两组患者的临床效果。结果治疗组的总有效率为93.33%,显著高于对照组的73.33%,组间差异有统计学意义(P<0.05)。结论纳洛酮联合无创正压通气治疗慢性阻塞性肺疾病合并呼吸衰竭的临床疗效显著,可以有效降低患者的痛苦,改善患者的缺氧及CO2潴留情况,适应性好,值得临床推广应用。
Objective To investigate the clinical efficacy of naloxone combined with noninvasive positive pressure ventilation in the treatment of chronic obstructive pulmonary disease with respiratory failure. Methods Sixty patients with chronic obstructive pulmonary disease and respiratory failure who were admitted to our hospital were randomly divided into treatment group (n = 30) and control group (n = 30). The treatment group received naloxone combined with non-invasive positive pressure ventilation, while the control group received naloxone alone , Comparing the clinical effect of two groups of patients. Results The total effective rate of the treatment group was 93.33%, which was significantly higher than that of the control group (73.33%). The difference between the two groups was statistically significant (P <0.05). Conclusion Naloxone combined with noninvasive positive pressure ventilation has significant clinical curative effect on chronic obstructive pulmonary disease combined with respiratory failure, which can effectively reduce the patient’s pain, improve patients’ hypoxia and CO2 retention, and has good adaptability and worthy of clinical application.